By Susan L. McElroy, Paul E. Keck Jr., Robert M. Post
Numerous antiepileptic medicinal drugs (AEDs) now have regulatory symptoms for treating bipolar affliction. there's growing to be facts that AEDs usually have a number of precious psychotropic results. This publication is the 1st entire, clinically orientated, reference at the use of AEDs to regard numerous psychiatric problems reminiscent of temper, psychotic, nervousness, substance use, consuming, and character issues. Written via the top scientific specialists, Antiepileptic medicinal drugs to regard Psychiatric issues: is prepared via psychiatric ailment for simpler info collecting, and permits the doctor to take advantage of the textual content as a stand by myself reference is the 1st accomplished reference ebook clinically oriented to using AEDs to regard psychiatric disorders—other books have eager about drug mechanisms and drug interactions
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Extra info for Antiepileptic Drugs to Treat Psychiatric Disorders (Medical Psychiatry Series)
SC, ICV, IT zonisamide dose-dependently ; thermal 8 hyperalgesia and tactile allodynia in rats. IP zonisamide dose-dependently ; thermal 13 hyperalgesia but has minimal effect on mechanical allodynia in rats. 3d] [29/4/08/1:35:8] [33–86] Antiepileptic Drugs in the Treatment of Neuropathic Pain 35 TABLE 1 (Continued ) Model Drug Effect Sciatic transection and dorsal cervical rhizotomy (models of deafferentation pain) Streptozotocin (model of diabetic neuropathy) Phenobarbital IM phenobarbital dose-dependently delays the onset and reduces the magnitude of pain.
Effect of age on epilepsy and its treatment: results from the VA cooperative study. Epilepsia 1994; 35 (suppl 8):91 (abstr). 35. Brodie MJ, Overstall PW, Giorgi L. for the UK Lamotrigine Elderly Study Group. Multicentre, double-blind, randomised comaprison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. Epilepsy Res 1999; 37:81–87. 36. Rowan AJ, Ramsay RE, Collins JF, et al. VA cooperative study 428 group. New onset geriatric epilepsy: a randomised study of gabapentin, lamotrigine, and carbamazepine.
Little is known of the teratogenic risks associated with the newer generation AEDs, with the exception of lamotrigine, a drug quite frequently used during pregnancy. 3d] [29/4/08/11:27:19] [17–32] Antiepileptics in the Treatment of Epilepsy 23 associated with carbamazepine (22). However, one study found a dose-effect relationship also for lamotrigine teratogenicity, so that at lamotrigine dosages greater than 200 mg/day, the malformation rate was similar to that associated with exposure to valproate 600 to 1000 mg/day (22).